Sleep of Patients with Schizophrenia On and Off Melatonin Treatment: Contradictions and Hypothesis
نویسنده
چکیده
Positive symptoms in schizophrenia decrease the requirement for REM sleep and reduce its pressure, while negative symptoms increase the need for REM sleep. This need cannot be satisfied because REM sleep in schizophrenia is functionally insufficient. This insufficiency may relate to the decreased melatonin level. Melatonin treatment restores REM-sleep functional efficiency in patients with different mental disorders, probably also in schizophrenia. There are some signs that melatonin inhibits brain dopamine systems that are active in wakefulness and that stimulate the dopamine system responsible for REM sleep-dreams sufficiency.
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